The Vestibular Genetics Laboratory, under the direction of Dr. Yesha Lundberg, conducts research to uncover the genetic, molecular and cellular mechanisms underlying the normal and abnormal development and maintenance of the vestibular (balance) system, with otoconia as the focus. We are also interested in the genetics of hearing loss. We use mouse models as well as human genetic and genomic approaches.
Our studies are aimed to identify the molecular and genetic causes of inner-ear diseases, particularly vestibular diseases. These studies can eventually help develop better diagnostic and treatment methods for prevention and early intervention.
Over 7 million adults in the United States suffer chronic vertigo of vestibular origin. Such illnesses are very disruptive to daily living. The most common balance disorder is benign paroxysmal positional vertigo (BPPV), which is believed to be caused by dislocation of otoconia.
Our studies show that many BPPV patients also have hearing loss. In all, about 30 million Americans have some kind of hearing loss. While many hearing loss genes have been identified in children, much fewer studies have been done in adults. The second goal of our studies is to identify molecular and genetic causes of age-related hearing loss.
Another project under way is the genetics of BOR (branchio-oto-renal) syndrome. BOR is an autosomal dominant birth defect that causes malformations of the ears (including hearing loss) and kidneys.
Please email firstname.lastname@example.org or call 1-402-498-6336 if you are interested in participating in our studies or have questions for us.
Yesha Lundberg, Ph.D., Director of the Vestibular Genetics Laboratory
Yinfang Xu, Ph.D., Senior Research Associate, email@example.com
Yesha Lundberg in PubMed1
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